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KMID : 0616120110420020182
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 2 p.182 ~ p.186
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Effects of Houttuynia cordata Thunb Extract Inhibits on the Migration and Proliferation of Vascular Smooth Muscle Cell
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Han Jung-ho
Park Seon-nam
Yoon Mi-So
Choi Ok-Byung
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Abstract
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Houttuynia cordata Thunb.[H.cordata]belonging to Saururaceae, is a wild medicinal herb of perennial plants, and grows well in a place with a lot of shade and moisture. The medical action of H.cordata is reported to have an antitumer effect, toxicity-suppressive effect, antifungal effect, diuretic effect, and antioxidative action, but its effect hasn’t been reported on cardiovascular diseases, such as ateriosclerosis and hypertension yet. This study intended to confirm the effect of the water extract of H.cordata on the migration and proliferation of rat aortic smooth muscle cells. Such results show that the water extract of H.cordata suppresses the migration and proliferation of rat aortic smooth muscle cells. It is believed that a useful clue will be offered later to the prevention of cardiovascular diseases such as ateriosclerosis and hypertension, and the development of their medicines on the basis of the fact.
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KEYWORD
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Houttuynia cordata Thunb.[H.cordata], migration, proliferation, PDGF-BB(Platelet-Derived Growth Factor)
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